Undruggable: Is the impossible now possible?

I was inspired to become an oncologist in part by a weekend of rounding with Daniel Von Hoff. So, when Dr. Von Hoff gives something the thumbs up,I pay attention. Several proteins in the body have been termed “undruggable.” Now, however, there is an U.S. Food and Drug Administration (FDA)-approved drug for “undruggable” kras mutant proteins. Proliferating cell nuclear antigen (PCNA) pro...